Single-cell heterogeneity in ribosome content and the consequences for the growth laws.

ABSTRACT: Across species and environments, the ribosome content of cell populations correlates with population growth rate. The robustness and universality of this correlation have led to its classification as a "growth law." This law has fueled theories about how evolution selects for microbial organisms that maximize their growth rate based on nutrient availability, and it has informed models about how individual cells regulate their growth rates and ribosomal content. However, due to methodological limitations, this growth law has rarely been studied at the level of individual cells. While populations of fast-growing cells tend to have more ribosomes than populations of slow-growing cells, it is unclear whether individual cells tightly regulate their ribosome content to match their

SUBMITTER: Brettner L 

PROVIDER: S-EPMC11185559 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature