The small non-coding RNA <i>Vaultrc5</i> is dispensable to mouse development.

ABSTRACT: Vault RNAs (vRNAs) are evolutionarily conserved small non-coding RNAs transcribed by RNA polymerase lll. Initially described as components of the vault particle, they have since also been described as noncanonical miRNA precursors and as riboregulators of autophagy. As central molecules in these processes, vRNAs have been attributed numerous biological roles including regulation of cell proliferation and survival, response to viral infections, drug resistance, and animal development. Yet, their impact to mammalian physiology remains largely unexplored. To study vault RNAs in vivo, we generated a mouse line with a conditional Vaultrc5 loss of function allele. Because Vaultrc5 is the sole murine vRNA, this allele enables the characterization of the physiological requirem

SUBMITTER: Prajapat M 

PROVIDER: S-EPMC11185573 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature