Disruption of recombination machinery alters the mutational landscape in plant organellar genomes.

ABSTRACT: Land plant organellar genomes have extremely low rates of point mutation yet also experience high rates of recombination and genome instability. Characterizing the molecular machinery responsible for these patterns is critical for understanding the evolution of these genomes. While much progress has been made towards understanding recombination activity in land plant organellar genomes, the relationship between recombination pathways and point mutation rates remains uncertain. The organellar targeted mutS homolog MSH1 has previously been shown to suppress point mutations as well as non-allelic recombination between short repeats in Arabidopsis thaliana. We therefore implemented high-fidelity Duplex Sequencing to test if other genes that function in recombination and maintenan

SUBMITTER: Waneka G 

PROVIDER: S-EPMC11185577 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature