Using lifestyle information in polygenic modeling of blood pressure traits: a simple method to reduce bias.

ABSTRACT: Complex traits are determined by the effects of multiple genetic variants, multiple environmental factors, and potentially their interaction. Predicting complex trait phenotypes from genotypes is a fundamental task in quantitative genetics that was pioneered in agricultural breeding for selection purposes. However, it has recently become important in human genetics. While prediction accuracy for some human complex traits is appreciable, this remains low for most traits. A promising way to improve prediction accuracy is by including not only genetic information but also environmental information in prediction models. However, environmental factors can, in turn, be genetically determined. This phenomenon gives rise to a correlation between the genetic and environmental components of the phen

SUBMITTER: Tiezzi F 

PROVIDER: S-EPMC11185601 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature