Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations.

ABSTRACT: Population genetic theory, and the empirical methods built upon it, often assume that individuals pair randomly for reproduction. However, natural populations frequently violate this assumption, which may potentially confound genome-wide association studies, selection scans, and demographic inference. Within several recently admixed human populations, empirical genetic studies have reported a correlation in global ancestry proportion between spouses, referred to as ancestry-assortative mating. Here, we use forward genomic simulations to link correlations in global ancestry proportion between mates to the underlying mechanistic mate-choice process. We consider the impacts of two types of mate-choice model, using either ancestry-based preferences or social groups as the basis for mate pairin

SUBMITTER: Massey DJ 

PROVIDER: S-EPMC11185628 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature