An updated compendium and reevaluation of the evidence for nuclear transcription factor occupancy over the mitochondrial genome.

ABSTRACT: In most eukaryotes, mitochondrial organelles contain their own genome, usually circular, which is the remnant of the genome of the ancestral bacterial endosymbiont that gave rise to modern mitochondria. Mitochondrial genomes are dramatically reduced in their gene content due to the process of endosymbiotic gene transfer to the nucleus; as a result most mitochondrial proteins are encoded in the nucleus and imported into mitochondria. This includes the components of the dedicated mitochondrial transcription and replication systems and regulatory factors, which are entirely distinct from the information processing systems in the nucleus. However, since the 1990s several nuclear transcription factors have been reported to act in mitochondria, and previously we identified 8 human and 3 mouse tr

SUBMITTER: Marinov GK 

PROVIDER: S-EPMC11185660 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature