Spike Reliability is Cell-Type Specific and Shapes Excitation and Inhibition in the Cortex.

ABSTRACT: Neurons encode information in the highly variable spiking activity of neuronal populations, so that different repetitions of the same stimulus can generate action potentials that vary significantly in terms of the count and timing. How does spiking variability originate, and does it have a functional purpose? Leveraging the Allen Institute cell types dataset, we relate the spiking reliability of cortical neurons in-vitro during the intracellular injection of current resembling synaptic inputs to their morphologic, electrophysiologic, and transcriptomic classes. Our findings demonstrate that parvalbumin+ (PV) interneurons, a subclass of inhibitory neurons, show high reliability compared to other neuronal subclasses, particularly excitatory neurons. Through computational modeling, we

SUBMITTER: Russo S 

PROVIDER: S-EPMC11185694 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature