The <i>Capicua</i> C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein.

ABSTRACT: Rearrangements between genes can yield neomorphic fusions that drive oncogenesis. Fusion oncogenes are made up of fractional segments of the partner genes that comprise them, with each partner potentially contributing some of its own function to the nascent fusion oncoprotein. Clinically, fusion oncoproteins driving one diagnostic entity are typically clustered into a single molecular subset and are often treated a similar fashion. However, knowledge of where specific fusion breakpoints occur in partner genes, and the resulting retention of functional domains in the fusion, is an important determinant of fusion oncoprotein activity and may differ between patients. This study investigates this phenomena through the example of CIC::DUX4, a fusion between the transcriptional repressor capicua

SUBMITTER: Luck C 

PROVIDER: S-EPMC11185703 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature