Directionality bias underpins divergent spatiotemporal progression of Alzheimer-related tauopathy in mouse models.

ABSTRACT: Mounting evidence implicates trans-synaptic connectome-based spread as a shared mechanism behind different tauopathic conditions, yet also suggests there is divergent spatiotemporal progression between them. A potential parsimonious explanation for this apparent contradiction could be that different conditions incur differential rates and directional biases in tau transmission along fiber tracts. In this meta-analysis we closely examined this hypothesis and quantitatively tested it using spatiotemporal tau pathology patterns from 11 distinct models across 4 experimental studies. For this purpose, we extended a network-based spread model by incorporating net directionality along the connectome. Our data unambiguously supports the directional transmission hypothesis. First, retrograde bias i

SUBMITTER: Torok J 

PROVIDER: S-EPMC11185722 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature