Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the developed world, and the number of people affected is expected to almost double by 2040. The retina presents one of the highest metabolic demands in our bodies that is partially or fully fulfilled by mitochondria in the neuroretina and retinal pigment epithelium (RPE), respectively. Together with its post-mitotic status and constant photooxidative damage from incoming light, the retina requires a tightly-regulated housekeeping system that involves autophagy. The natural polyphenol Urolithin A (UA) has shown neuroprotective benefits in several models of aging and age-associated disorders, mostly attributed to its ability to induce mitophagy and mitochondrial biogenesis. Sodiu

SUBMITTER: Jimenez-Loygorri JI 

PROVIDER: S-EPMC11186080 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature