Causality between serum uric acid and diabetic microvascular complications - a mendelian randomization study.

ABSTRACT:

Background

The aim of this study was to investigate whether a causal relationship exists between serum uric acid (SUA) and diabetic microvascular complications using a two-sample Mendelian randomization (MR) method.

Methods

We used the MR approach, utilizing genome-wide association study (GWAS) summary statistics, to estimate the causal effect of SUA on diabetic microvascular complications in European individuals. The summary statistical data of SUA were obtained from the open database (IEU OPEN GWAS PROJECT) (p < 5 × 10^- 8), and data on diabetic microvascular complications (diabetic nephropathy, diabetic neuropathy, diabetic retinopathy) were obtained from the FinnGen consortium. F-statistics were calculated to assess the correlation between instrumental variable

SUBMITTER: Wu H 

PROVIDER: S-EPMC11186091 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature