Autophagy-related molecular clusters identified as indicators for distinguishing active and latent TB infection in pediatric patients.

ABSTRACT:

Background

Autophagy is crucial for controlling the manifestation of tuberculosis. This study intends to discover autophagy-related molecular clusters as biomarkers for discriminating between latent tuberculosis (LTBI) and active tuberculosis (ATB) in children through gene expression profile analysis.

Methods

The expression of autophagy modulators was examined in pediatric patients with LTBI and ATB utilizing public datasets from the Gene Expression Omnibus (GEO) collection (GSE39939 and GSE39940).

Results

In a training dataset (GSE39939), patients with LTBI and ATB exhibited the expression of autophagy-related genes connected with their active immune responses. Two molecular clusters associated with autophagy were identified. Compared to Cluster 1, Cluster 2 was dist

SUBMITTER: Yu Y 

PROVIDER: S-EPMC11186109 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature