Hypersensitivity to BK_Ca channel opening in persistent post-traumatic headache.

ABSTRACT:

Background

Large conductance  calcium-activated potassium (BK_Ca) channels have been implicated in the neurobiological underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we aimed to examine whether MaxiPost (a BK_Ca channel opener) could induce migraine-like headache in persons with PPTH.

Methods

This is a randomized double-blind, placebo-controlled, two-way crossover study from September 2023 to December 2023. Eligible participants were adults with PPTH after mild traumatic brain injury who reported having no personal history of migraine. The randomized participants received a single dose of either MaxiPost (0.05 mg/min) or placebo (isotonic saline) that was infused intravenous

SUBMITTER: Al-Khazali HM 

PROVIDER: S-EPMC11186171 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature