Basement membrane-related MMP14 predicts poor prognosis and response to immunotherapy in bladder cancer.

ABSTRACT:

Background

Basement membrane (BM) is an important component of the extracellular matrix, which plays an important role in the growth and metastasis of tumor cells. However, few biomarkers based on BM have been developed for prognostic assessment and prediction of immunotherapy in bladder cancer (BLCA).

Methods

In this study, we used the BLCA public database to explore the relationship between BM-related genes (BMRGs) and prognosis. A novel molecular typing of BLCA was performed using consensus clustering. LASSO regression was used to construct a signature based on BMRGs, and its relationship with prognosis was explored using survival analysis. The pivotal BMRGs were further analyzed to assess its clinical characteristics and immune landscape. Finally, immunohistochemistry wa

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11186261 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature