Kainate receptor channel opening and gating mechanism.

ABSTRACT: Kainate receptors, a subclass of ionotropic glutamate receptors, are tetrameric ligand-gated ion channels that mediate excitatory neurotransmission^1-4. Kainate receptors modulate neuronal circuits and synaptic plasticity during the development and function of the central nervous system and are implicated in various neurological and psychiatric diseases, including epilepsy, depression, schizophrenia, anxiety and autism^5-11. Although structures of kainate receptor domains and subunit assemblies are available^12-18, the mechanism of kainate receptor gating remains poorly understood. Here we present cryo-electron microscopy structures of the kainate receptor GluK2 in the presence of the agonist glutamate and the positive allosteric modulators lectin concanavalin

SUBMITTER: Gangwar SP 

PROVIDER: S-EPMC11186766 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature