Myelin plasticity in the ventral tegmental area is required for opioid reward.

ABSTRACT: All drugs of abuse induce long-lasting changes in synaptic transmission and neural circuit function that underlie substance-use disorders^1,2. Another recently appreciated mechanism of neural circuit plasticity is mediated through activity-regulated changes in myelin that can tune circuit function and influence cognitive behaviour^3-7. Here we explore the role of myelin plasticity in dopaminergic circuitry and reward learning. We demonstrate that dopaminergic neuronal activity-regulated myelin plasticity is a key modulator of dopaminergic circuit function and opioid reward. Oligodendroglial lineage cells respond to dopaminergic neuronal activity evoked by optogenetic stimulation of dopaminergic neurons, optogenetic inhibition of GABAergic neurons, or administration of m

SUBMITTER: Yalcın B 

PROVIDER: S-EPMC11186775 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature