Identifying novel proteins for migraine by integrating proteomes from blood and CSF with genome-wide association data.

ABSTRACT:

Background

Proteome-wide Mendelian randomization studies have been increasingly utilized to identify potential drug targets for diseases. We aimed to identify potential therapeutic targets for migraine and its subtypes through the application of Mendelian randomization and co-localization analysis methods.

Methods

We utilized cis-protein quantitative trait loci data for 1378 plasma proteins available from two studies with 7213 individuals and 35,559 individuals, respectively. Summary data for migraine and its subtypes were obtained from a genetic study involving up to 1,339,303 individuals. Proteins that passed both the discovery and validation Mendelian randomization analysis, sensitivity analysis, heterogeneity test, and pleiotropy test, were associated with ≥2 outcomes, a

SUBMITTER: Niu PP 

PROVIDER: S-EPMC11186850 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature