Quantitative proteomics reveals cellular responses to individual mAb expression and tunicamycin in CHO cells.

ABSTRACT: Chinese hamster ovary (CHO) cells are popular in the pharmaceutical industry for their ability to produce high concentrations of antibodies and their resemblance to human cells in terms of protein glycosylation patterns. Current data indicate the relevance of CHO cells in the biopharmaceutical industry, with a high number of product commendations and a significant market share for monoclonal antibodies. To enhance the production capabilities of CHO cells, a deep understanding of their cellular and molecular composition is crucial. Genome sequencing and proteomic analysis have provided valuable insights into the impact of the bioprocessing conditions, productivity, and product quality. In our investigation, we conducted a comparative analysis of proteomic profiles in high and low monoclonal

SUBMITTER: Sulaj E 

PROVIDER: S-EPMC11186912 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature