Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells.

ABSTRACT: Ovarian cancer often develops resistance to conventional therapies, hampering their effectiveness. Here, using ex vivo paired ovarian cancer ascites obtained before and after chemotherapy and in vitro therapy-induced secretomes, we show that molecules secreted by ovarian cancer cells upon therapy promote cisplatin resistance and enhance DNA damage repair in recipient cancer cells. Even a short-term incubation of chemonaive ovarian cancer cells with therapy-induced secretomes induces changes resembling those that are observed in chemoresistant patient-derived tumor cells after long-term therapy. Using integrative omics techniques, we find that both ex vivo and in vitro therapy-induced secretomes are enriched with spliceosomal components, which relocalize from the nucleus to the cytoplasm an

SUBMITTER: Shender VO 

PROVIDER: S-EPMC11187153 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature