Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10⁺ Breg cells and protect against T1D.

ABSTRACT:

Introduction

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β cells. Toll-like receptor 9 (TLR9) plays a role in autoimmune diseases, and B cell-specific TLR9 deficiency delays T1D development. Gut microbiota are implicated in T1D, although the relationship is complex. However, the impact of B cell-specific deficiency of TLR9 on intestinal microbiota and the impact of altered intestinal microbiota on the development of T1D are unclear.

Objectives

This study investigated how gut microbiota and the intestinal barrier contribute to T1D development in B cell-specific TLR9-deficient NOD mice. Additionally, this study explored the role of microbiota in immune regulation and T1D onset.

Methods

The study assessed gut perme

SUBMITTER: Yang X 

PROVIDER: S-EPMC11187306 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature