Therapeutic targets for age-related macular degeneration: proteome-wide Mendelian randomization and colocalization analyses.

ABSTRACT:

Background

Currently, effective therapeutic drugs for age-related macular degeneration (AMD) are urgently needed, and it is crucial to explore new treatment targets. The proteome is indispensable for exploring disease targets, so we conducted a Mendelian randomization (MR) of the proteome to identify new targets for AMD and its related subtypes.

Methods

The plasma protein level data used in this study were obtained from two large-scale studies of protein quantitative trait loci (pQTL), comprising 35,559 and 54,219 samples, respectively. The expression quantitative trait loci (eQTL) data were sourced from eQTLGen and GTEx Version 8. The discovery set for AMD data and subtypes was derived from the FinnGen study, consisting of 9,721 AMD cases and 381,339 controls, 5,239 wet AMD

SUBMITTER: Pu KL 

PROVIDER: S-EPMC11187347 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature