Rosavin improves insulin resistance and alleviates hepatic and kidney damage <i>via</i> modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals.

ABSTRACT: Background: Inflammation-mediated insulin resistance in type 2 diabetes mellitus (T2DM) increases complications, necessitating investigation of its mechanism to find new safe therapies. This study investigated the effect of rosavin on the autophagy and the cGAS-STING pathway-related signatures (ZBP1, STING1, DDX58, LC3B, TNF-α) and on their epigenetic modifiers (miR-1976 and lncRNA AC074117.2) that were identified from in silico analysis in T2DM animals. Methods: A T2DM rat model was established by combining a high-fat diet (HFD) and streptozotocin (STZ). After four weeks from T2DM induction, HFD/STZ-induced T2DM rats were subdivided into an untreated group (T2DM group) and three treated groups which received 10, 20, or 30 mg per kg of R. rosea daily for 4 weeks

SUBMITTER: Ali HS 

PROVIDER: S-EPMC11187545 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature