Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer.

ABSTRACT: Alzheimer's disease (AD) and cancer are among the most devastating diseases of the 21st century. Although the clinical manifestations are different and the cellular mechanisms underlying the pathologies are opposite, there are different classes of molecules that are effective in both diseases, such as quinone-based compounds and histone deacetylase inhibitors (HDACIs). Herein, we investigate the biological effects of a series of compounds built to exploit the beneficial effects of quinones and histone deacetylase inhibition (compounds 1-8). Among the different compounds, compound 6 turned out to be a potent cytotoxic agent in SH-SY5Y cancer cell line, with a half maximal inhibitory concentration (IC₅₀) value lower than vorinostat and a pro-apoptotic activity. On the other hand,

SUBMITTER: Guardigni M 

PROVIDER: S-EPMC11187553 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature