Phenylthiazoles with potent & optimum selectivity toward <i>Clostridium difficile</i>.

ABSTRACT: Clostridium difficile (C. difficile) is one of the most threatening bacteria globally, causing high mortality and morbidity in humans and animals, and is considered a public health threat that requires urgent and aggressive action. Interruption of the human gut microbiome and the development of antibiotic resistance urgently require development and synthesis of effective alternative antibiotics with minimal effects on the normal gut microbial flora. In this study, cyclization of the aminoguanidine head to the thiazole nucleus while maintaining its other pharmacophoric features leads to selective targeting of Clostridioides difficile as shown in the graphical abstract. The most promising compound, 5, was significantly more efficient than vancomycin and metronidazole aga

SUBMITTER: Seif El-Din MM 

PROVIDER: S-EPMC11187570 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature