Human milk oligosaccharides regulate human macrophage polarization and activation in response to Staphylococcus aureus.

ABSTRACT: Human milk oligosaccharides (HMOs) are present in high numbers in milk of lactating women. They are beneficial to gut health and the habitant microbiota, but less is known about their effect on cells from the immune system. In this study, we investigated the direct effect of three structurally different HMOs on human derived macrophages before challenge with Staphylococcus aureus (S. aureus). The study demonstrates that individual HMO structures potently affect the activation, differentiation and development of monocyte-derived macrophages in response to S. aureus. 6´-Sialyllactose (6'SL) had the most pronounced effect on the immune response against S. aureus, as illustrated by altered expression of macrophage surface markers, pointing towards an activated M1-li

SUBMITTER: Jepsen SD 

PROVIDER: S-EPMC11187579 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature