Nested Biofabrication: Matryoshka-Inspired Intra-Embedded Bioprinting.

ABSTRACT: Engineering functional tissues and organs remains a fundamental pursuit in bio-fabrication. However, the accurate constitution of complex shapes and internal anatomical features of specific organs, including their intricate blood vessels and nerves, remains a significant challenge. Inspired by the Matryoshka doll, here a new method called "Intra-Embedded Bioprinting (IEB)" is introduced building upon existing embedded bioprinting methods. a xanthan gum-based material is used which served a dual role as both a bioprintable ink and a support bath, due to its unique shear-thinning and self-healing properties. IEB's capabilities in organ modeling, creating a miniaturized replica of a pancreas using a photocrosslinkable silicone composite is demonstrated. Further, a head phantom and a Matryoshk

SUBMITTER: Alioglu MA 

PROVIDER: S-EPMC11187694 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature