Sex Differences in Sympathetic Responses to Lower-Body Negative Pressure.

ABSTRACT:

Introduction

Trauma-induced hemorrhage is a leading cause of death in prehospital settings. Experimental data demonstrate that females have a lower tolerance to simulated hemorrhage (i.e., central hypovolemia). However, the mechanism(s) underpinning these responses are unknown. Therefore, this study aimed to compare autonomic cardiovascular responses during central hypovolemia between the sexes. We hypothesized that females would have a lower tolerance and smaller increase in muscle sympathetic nerve activity (MSNA) to simulated hemorrhage.

Methods

Data from 17 females and 19 males, aged 19-45 yr, were retrospectively analyzed. Participants completed a progressive lower-body negative pressure (LBNP) protocol to presyncope to simulate hemorrhagic tolerance with continuous mea

SUBMITTER: Jarrard CP 

PROVIDER: S-EPMC11187698 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature