Relationship between alcohol consumption and dementia with Mendelian randomization approaches among older adults in the United States.

ABSTRACT:

Introduction

In observational studies, the association between alcohol consumption and dementia is mixed.

Methods

We performed two-sample Mendelian randomization (MR) using summary statistics from genome-wide association studies of weekly alcohol consumption and late-onset Alzheimer's disease and one-sample MR in the Health and Retirement Study (HRS), wave 2012. Inverse variance weighted two-stage regression provided odds ratios of association between alcohol exposure and dementia or cognitively impaired, non-dementia relative to cognitively normal.

Results

Alcohol consumption was not associated with late-onset Alzheimer's disease using two-sample MR (odds ratio [OR] = 1.15, 95% confidence interval [CI]: [0.78, 1.72]). In HRS, doubling weekly alcohol consumption was n

SUBMITTER: Campbell KA 

PROVIDER: S-EPMC11187745 | biostudies-literature | 2024 Apr-Jun

REPOSITORIES: biostudies-literature