Comparison of genetic and epigenetic profiles of periodontitis according to the presence of type 2 diabetes.

ABSTRACT: Type 2 diabetes mellitus (T2DM) and periodontitis (PD) have intricated connections as chronic inflammatory diseases. While the immune response is a key factor that accounts for their association, the underlying mechanisms remain unclear. To gain a deeper understanding of the connection, we conducted research using a multiomics approach. We generated whole genome and methylation profiling array data from the periodontium of PD patients with DM (PDDM) and without DM to confirm genetic and epigenetic changes. Independent bulk and single-cell RNA sequencing data were employed to verify the expression levels of hypo-methylated genes. We observed a gradual rise in C>T base substitutions and hypomethylation in PD and PDDM patients compared with healthy participants. Furthermore, specific genetic

SUBMITTER: Kang J 

PROVIDER: S-EPMC11187843 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature