Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis.

ABSTRACT:

Objective

Comorbid anxiety occurs often in MS and is associated with disability progression. Polygenic scores offer a possible means of anxiety risk prediction but often have not been validated outside the original discovery population. We aimed to investigate the association between the Generalized Anxiety Disorder 2-item scale polygenic score with anxiety in MS.

Methods

Using a case-control design, participants from Canadian, UK Biobank, and United States cohorts were grouped into cases (MS/comorbid anxiety) or controls (MS/no anxiety, anxiety/no immune disease or healthy). We used multiple anxiety measures: current symptoms, lifetime interview-diagnosed, and lifetime self-report physician-diagnosed. The polygenic score was computed for current anxiety symptoms using summa

SUBMITTER: Kowalec K 

PROVIDER: S-EPMC11187942 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature