Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure.

ABSTRACT:

Objective

Alzheimer's disease (AD) and cerebral small vessel disease (cSVD), the two most common causes of dementia, are characterized by white matter (WM) alterations diverging from the physiological changes occurring in healthy aging. Diffusion tensor imaging (DTI) is a valuable tool to quantify WM integrity non-invasively and identify the determinants of such alterations. Here, we investigated main effects and interactions of AD pathology, APOE-ε4, cSVD, and cardiovascular risk on spatial patterns of WM alterations in non-demented older adults.

Methods

Within the prospective European Prevention of Alzheimer's Dementia study, we selected 606 participants (64.9 ± 7.2 years, 376 females) with baseline cerebrospinal fluid samples of amyloid β_1-42 and p-Tau_181<

SUBMITTER: Tranfa M 

PROVIDER: S-EPMC11187968 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature