Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years.

ABSTRACT: The multi-millenia long history between dogs and humans has placed them at the forefront of archeological and genomic research. Despite ongoing efforts including the analysis of ancient dog and wolf genomes, many questions remain regarding their geographic and temporal origins, and the microevolutionary processes that led to the diversity of breeds today. Although ancient genomes provide valuable information, their use is hindered by low depth of coverage and post-mortem damage, which inhibits confident genotype calling. In the present study, we assess how genotype imputation of ancient dog and wolf genomes, utilising a large reference panel, can improve the resolution provided by ancient datasets. Imputation accuracy was evaluated by down-sampling high coverage dog and wolf genomes to 0.0

SUBMITTER: Bougiouri K 

PROVIDER: S-EPMC11188068 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature