The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes.

ABSTRACT:

Introduction

By integrating genetic and clinical risk factors into genomic-informed dementia risk reports, healthcare providers can offer patients detailed risk profiles to facilitate understanding of individual risk and support the implementation of personalized strategies for promoting brain health.

Methods

We constructed an additive score comprising the modified Cardiovascular Risk Factors, Aging, and Incidence of Dementia Risk Score (mCAIDE), family history of dementia, APOE genotype, and an AD polygenic risk score in NACC and ADNI, and assessed its association with progression to all-cause dementia.

Results

81% of participants had at least one high-risk indicator for dementia, with each additional risk indicator linked to a 34% increase in the hazard of de

SUBMITTER: Andrews SJ 

PROVIDER: S-EPMC11188112 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature