Molecular genomic and epigenomic characteristics related to aspirin and clopidogrel resistance.

ABSTRACT:

Background

Mediators, genomic and epigenomic characteristics involving in metabolism of arachidonic acid by cyclooxygenase (COX) and lipoxygenase (ALOX) and hepatic activation of clopidogrel have been individually suggested as factors associated with resistance against aspirin and clopidogrel. The present multi-center prospective cohort study evaluated whether the mediators, genomic and epigenomic characteristics participating in arachidonic acid metabolism and clopidogrel activation could be factors that improve the prediction of the aspirin and clopidogrel resistance in addition to cardiovascular risks.

Methods

We enrolled 988 patients with transient ischemic attack and ischemic stroke who were evaluated for a recurrence of ischemic stroke to confirm clinical resistance, a

SUBMITTER: Kim J 

PROVIDER: S-EPMC11188263 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature