Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota.

ABSTRACT: Microbiome research has gained much attention in recent years as the importance of gut microbiota in regulating host health becomes increasingly evident. However, the impact of radiation on the microbiota in the murine bone marrow transplantation model is still poorly understood. In this paper, we present key findings from our study on how radiation, followed by bone marrow transplantation with or without T cell depletion, impacts the microbiota in the ileum and caecum. Our findings show that radiation has different effects on the microbiota of the two intestinal regions, with the caecum showing increased interindividual variation, suggesting an impaired ability of the host to regulate microbial symbionts, consistent with the Anna Karenina principle. Additionally, we observed changes in th

SUBMITTER: Kreisinger J 

PROVIDER: S-EPMC11188301 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature