Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice.

ABSTRACT:

Introduction

Caloric restriction (CR) is a nutritional intervention that increases life expectancy while lowering the risk for cardio-metabolic disease. Its effects on bone health, however, remain controversial. For instance, CR has been linked to increased accumulation of bone marrow adipose tissue (BMAT) in long bones, a process thought to elicit detrimental effects on bone. Qualitative differences have been reported in BMAT in relation to its specific anatomical localization, subdividing it into physiological and potentially pathological BMAT. We here examine the local impact of CR on bone composition, microstructure and its endocrine profile in the context of aging.

Methods

Young and aged male C57Bl6J mice were subjected to CR for 8 weeks and were compared to age-matched

SUBMITTER: Rinne C 

PROVIDER: S-EPMC11188307 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature