Effect of progestin on thyroid function in female Wistar rats.

ABSTRACT:

Introduction

To characterize the influence of female-specific hormones on women's thyroid function, the study investigated the influence of extra progestin from oral contraceptives on inducing thyroid dysfunction.

Methods

Sixty female Wistar rats were divided into six groups based on levonorgestrel or desogestrel administration as the main active agents: control, low (0.0039 mg*20-fold), medium (0.0039 mg*100-fold), high (0.0318 mg*100-fold) levonorgestrel (pure product); and low (0.0083 mg*20-fold) and high (0.0083 mg*100-fold) desogestrel (pure product). Progestin was administered by gavage every 4 days for 1 month. Statistical analysis was performed using one-way analysis of variance and the Kruskal-Wallis test.

Results

Following levonorgestrel gavage, serum free T

SUBMITTER: Xie H 

PROVIDER: S-EPMC11188309 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature