Cathepsins and Parkinson's disease: insights from Mendelian randomization analyses.

ABSTRACT:

Background

Parkinson's disease (PD), the second most prevalent neurodegenerative condition, has a multifaceted etiology. Cathepsin-cysteine proteases situated within lysosomes participate in a range of physiological and pathological processes, including the degradation of harmful proteins. Prior research has pointed towards a potential link between cathepsins and PD; however, the precise causal relationship between the cathepsin family and PD remains unclear.

Methods

This study employed univariate and multivariate Mendelian randomization (MR) analyses to explore the causal relationship between the nine cathepsins and Parkinson's disease (PD) risk. For the primary analysis, genome-wide association study (GWAS) summary statistics for the plasma levels of the nine cathepsins an

SUBMITTER: Yusufujiang A 

PROVIDER: S-EPMC11188310 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature