Exploring early DNA methylation alterations in type 1 diabetes: implications of glycemic control.

ABSTRACT:

Background

Prolonged hyperglycemia causes diabetes-related micro- and macrovascular complications, which combined represent a significant burden for individuals living with diabetes. The growing scope of evidence indicates that hyperglycemia affects the development of vascular complications through DNA methylation.

Methods

A genome-wide differential DNA methylation analysis was performed on pooled peripheral blood DNA samples from individuals with type 1 diabetes (T1D) with direct DNA sequencing. Strict selection criteria were used to ensure two age- and sex-matched groups with no clinical signs of chronic complications according to persistent mean glycated hemoglobin (HbA1c) values over 5 years: HbA1c<7% (N=10) and HbA1c>8% (N=10).

Results

Between the two groups, 838

SUBMITTER: Cugalj Kern B 

PROVIDER: S-EPMC11188314 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature