Ceftazidime/avibactam resistance is associated with PER-3-producing ST309 lineage in Chilean clinical isolates of non-carbapenemase producing Pseudomonas aeruginosa.

ABSTRACT:

Introduction

Ceftazidime/avibactam (CZA) is indicated against multidrug-resistant Pseudomonas aeruginosa, particularly those that are carbapenem resistant. CZA resistance in P. aeruginosa producing PER, a class A extended-spectrum β-lactamase, has been well documented in vitro. However, data regarding clinical isolates are scarce. Our aim was to analyze the contribution of PER to CZA resistance in non-carbapenemase-producing P. aeruginosa clinical isolates that were ceftazidime and/or carbapenem non-susceptible.

Methods

Antimicrobial susceptibility was determined through agar dilution and broth microdilution, while bla _PER gene was screened through PCR. All PER-positive isolates and five PER-negative isolates were analyzed throug

SUBMITTER: Soto KD 

PROVIDER: S-EPMC11188487 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature