Upregulated miR-146b-3p predicted rheumatoid arthritis development and regulated TNF-α-induced excessive proliferation, motility, and inflammation in MH7A cells.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic immune system disease with a high disability rate threatening the living quality of patients. Identifying potential biomarkers for RA is of necessity to improve the prevention and management of RA.

Objectives

This study focused on miR-146b-3p evaluating its clinical significance and revealing the underlying regulatory mechanisms.

Materials and methods

A total of 107 RA patients were enrolled, and both serum and synovial tissues were collected. Another 78 osteoarthritis patients (OA, providing synovial tissues), and 72 healthy individuals (providing serum samples) were enrolled as the control group. The expression of miR-146b-3p was analyzed by PCR and analyzed with ROC and Pearson correlation analyses evaluating its si

SUBMITTER: Ma L 

PROVIDER: S-EPMC11188492 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature