Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction.

ABSTRACT:

Background

The immune system's role in ST-segment-elevated myocardial infarction (STEMI) remains poorly characterized but is an important driver of recurrent cardiovascular events. While anti-inflammatory drugs show promise in reducing recurrence risk, their broad immune system impairment may induce severe side effects. To overcome these challenges, a nuanced understanding of the immune response to STEMI is needed.

Methods

For this, we compared peripheral blood mononuclear single-cell RNA-sequencing (scRNA-seq) and plasma protein expression over time (hospital admission, 24 hours, and 6-8 weeks post-STEMI) in 38 patients and 38 controls (95 995 diseased and 33 878 control peripheral blood mononuclear cells).

Results

Compared with controls, classical monocytes were inc

SUBMITTER: van Blokland IV 

PROVIDER: S-EPMC11188632 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature