PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca²⁺ homeostasis in sensory neurons.

ABSTRACT: Pancreatic and duodenal homeobox 1 (PDX1) is a transcription factor required for the development and differentiation of the pancreas. Previous studies indicated that PDX1 expression was restricted to the gastrointestinal tract. Using a cre-dependent reporter, we observed PDX1-dependent expression of tdtomato (PDX1-tom) in a subpopulation of sensory nerves. Many of these PDX1-tom afferents expressed the neurofilament 200 protein and projected to the skin. Tdtomato-labeled terminals were associated with hair follicles in the form of longitudinal and circumferential lanceolate endings suggesting a role in tactile and proprioceptive perception. To begin to examine the functional significance of PDX1 in afferents, we used Fura-2 imaging to examine calcium (Ca²⁺) handling under naïve

SUBMITTER: Saloman JL 

PROVIDER: S-EPMC11188734 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature