Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study.

ABSTRACT:

Background

Previous observational studies have discovered a connection between depression and mineral status. Confirming this potential connection is challenging due to confounding factors and potential reverse causality which is inherent in observational studies.

Materials and methods

We performed a Mendelian randomization (MR) analysis to estimate the causal association of serum minerals with depression. Leveraging summary-level data on depression, a genome-wide association study (GWAS) was applied. The data on serum minerals were collected from the FinnGen Biobank database. MR assessments representing causality were produced by inverse-variance weighted approaches with multiplicative random and fixed effects.

Result

Sensitivity analyses were performed to validate t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11188766 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature