Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites.

ABSTRACT: Adenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic diversity in a temporal-spatial manner. The function and essentiality of a few conserved recoding sites are recognized. However, the experimentally discovered functional sites only make up a small corner of the total sites, and there is still the need to expand the repertoire of such functional sites with bioinformatic approaches. In this study, we define a new category of RNA editing sites termed 'conserved editing with non-conserved recoding' and systematically identify such sites in Drosophila editomes, figuring out their selection p

SUBMITTER: Duan Y 

PROVIDER: S-EPMC11188811 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature