Bone changes post-sleeve gastrectomy in relation to body mass and hormonal changes.

ABSTRACT:

Objective

To determine mechanisms contributing to impaired bone health in youth 24 months following sleeve gastrectomy (SG).

Design

Twenty-four-month longitudinal observational study.

Methods

Participants included 23 youth undergoing SG and 30 non-surgical controls (NS) 13-25 years old with moderate-to-severe obesity. Subjects underwent fasting labs for bone turnover markers (N-terminal propeptide of type 1 procollagen, C-telopeptide (CTX)), sex hormones, sex hormone binding globulin (SHBG), and enteric peptides, DXA for areal bone mineral density (aBMD) and body composition, high-resolution peripheral quantitative CT for volumetric BMD (vBMD) at the distal radius and tibia, and microfinite element analysis for strength estimates.

Results

Groups did not differ

SUBMITTER: Kaur S 

PROVIDER: S-EPMC11188938 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature