Gene regulation in activated microglia by adenosine A₃ receptor agonists: a transcriptomics study.

ABSTRACT: Most neurodegenerative disorders, including the two most common, Alzheimer's disease (AD) and Parkinson's disease (AD), course with activation of microglia, the resident innate immune cells of the central nervous system. A₃ adenosine receptor (A₃R) agonists have been proposed to be neuroprotective by regulating the phenotype of activated microglia. RNAseq was performed using samples isolated from lipopolysaccharide/interferon-γ activated microglia treated with 2-Cl-IB-MECA, a selective A₃R agonist. The results showed that the number of negatively regulated genes in the presence of 2-Cl-IB-MECA was greater than the number of positively regulated genes. Gene ontology enrichment analysis showed regulation of genes participating in several cell processes, inclu

SUBMITTER: Lillo A 

PROVIDER: S-EPMC11189369 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature