Candidate protein biomarkers in chronic kidney disease: a proteomics study.

ABSTRACT: Proteinuria poses a substantial risk for the progression of chronic kidney disease (CKD) and its related complications. Kidneys excrete hundreds of individual proteins, some with a potential impact on CKD progression or as a marker of the disease. However, the available data on specific urinary proteins and their relationship with CKD severity remain limited. Therefore, we aimed to investigate the urinary proteome and its association with kidney function in CKD patients and healthy controls. The proteomic analysis of urine samples showed CKD stage-specific differences in the number of detected proteins and the exponentially modified protein abundance index for total protein (p = 0.007). Notably, specific urinary proteins such as B2MG, FETUA, VTDB, and AMBP exhibited robust negative associa

SUBMITTER: Makhammajanov Z 

PROVIDER: S-EPMC11189417 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature