Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns.

ABSTRACT: Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings. Therefore, we investigated the transcriptomic characteristics of eight male healthy cynomolgus macaques, and the annual sampling was designed with two individuals in four age groups. As a laboratory animal, the macaques were meticulously shielded from all environmental factors except aging. The results showed recent findings of certain immune response and the age-associated network of primate immunity. Three important aging patterns were identified and each gene clusters represented a different immune response. The increased expression pattern was predominantly associated with innate immune cells, such as Neutrophils and NK cells, causing chr

SUBMITTER: Cho HM 

PROVIDER: S-EPMC11189941 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature