Characteristics of the gut microbiota and serum metabolites in postmenopausal women with reduced bone mineral density.

ABSTRACT:

Introduction

Emerging evidence suggests that the gut microbiota is closely associated with bone homeostasis. However, little is known about the relationships among the bone mineral density (BMD) index, bone turnover markers, and the gut microbiota and its metabolites in postmenopausal women.

Methods

In this study, to understand gut microbiota signatures and serum metabolite changes in postmenopausal women with reduced BMD, postmenopausal individuals with normal or reduced BMD were recruited and divided into normal and OS groups. Feces and serum samples were collected for 16S rRNA gene sequencing, liquid chromatography coupled with mass spectrometry (LC-MS)-based metabolomics and integrated analysis.

Results

The results demonstrated that bacterial richness and diversit

SUBMITTER: Yan L 

PROVIDER: S-EPMC11190063 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature